Fluid Flow Induced Calcium Response in Bone Cell Network
نویسندگان
چکیده
منابع مشابه
Fluid Flow Induced Calcium Response in Bone Cell Network.
In our previous work, bone cell networks with controlled spacing and functional intercellular gap junctions had been successfully established by using microcontact printing and self assembled monolayers technologies [Guo, X. E., E. Takai, X. Jiang, Q. Xu, G. M. Whitesides, J. T. Yardley, C. T. Hung, E. M. Chow, T. Hantschel, and K. D. Costa. Mol. Cell. Biomech. 3:95-107, 2006]. The present stud...
متن کاملIn Vitro 3D Bone Response to Fluid Flow-induced Shear Stress and Mechanical Strain
INTRODUCTION Mechanical loading is a critical factor in the bone remodeling process and subsequently the strength and structure of bone. Trabecular bone is subjected to a complex physical environment due to its complex microstructure. This results in bone cells, within the bone tissue, being exposed to various mechanical signals including fluid flow-induced shear stress and mechanical strain. M...
متن کاملFluid and Solute Transport in Bone: Flow-Induced Mechanotransduction.
Much recent evidence suggests that bone cells sense their mechanical environment via interstitial fluid flow. In this review, we summarize theoretical and experimental approaches to quantify fluid and solute transport in bone, starting with the early investigations of fluid shear stress applied to bone cells. The pathways of bone interstitial fluid and solute movement are high-lighted based on ...
متن کاملMAP kinase and calcium signaling mediate fluid flow-induced human mesenchymal stem cell proliferation.
Mechanical signals are important regulators of skeletal homeostasis, and strain-induced oscillatory fluid flow is a potent mechanical stimulus. Although the mechanisms by which osteoblasts and osteocytes respond to fluid flow are being elucidated, little is known about the mechanisms by which bone marrow-derived mesenchymal stem cells respond to such stimuli. Here we show that the intracellular...
متن کاملOsteocytic network is more responsive in calcium signaling than osteoblastic network under fluid flow.
Osteocytes, regarded as the mechanical sensor in bone, respond to mechanical stimulation by activating biochemical pathways and mediating the cellular activities of other bone cells. Little is known about how osteocytic networks respond to physiological mechanical stimuli. In this study, we compared the mechanical sensitivity of osteocytic and osteoblastic networks under physiological-related f...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cellular and Molecular Bioengineering
سال: 2008
ISSN: 1865-5025,1865-5033
DOI: 10.1007/s12195-008-0011-0